高原缺氧环境因氧分压降低、药物代谢改变及并发症风险增加，给麻醉管理带来独特挑战。青海大学附属医院研究团队通过大鼠模型模拟5000米海拔缺氧暴露72小时，首次系统评估瑞马唑仑(Remimazolam)的药代动力学与呼吸效应。研究发现：高原组大鼠血药峰浓度(Cmax ...

Exposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may be associated with worse outcomes in patients receiving extracorporeal membrane oxygenator (ECMO) support. We examined ...

Near-infrared spectroscopy (NIRS) measurement of regional cerebral tissue oxygen saturation (rcStO2) has become a topic of high interest in neonatology. Multiple studies have demonstrated that rcStO2 ...

To evaluate home noninvasive positive pressure ventilation (NIPPV) in adult patients with chronic respiratory failure in terms of initiation, continuation, effectiveness, adverse events, equipment ...

School of Chemistry, The University of Sydney, Sydney, NSW2006, Australia School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW2006, Australia ...

aBirmingham Acute Care Research Group, Institute of Inflammation and Ageing, New Queen Elizabeth Hospital, University of Birmingham, 1st Floor, Mindelsohn Way, Birmingham B15 2WB, United Kingdom ...

MW = molecular weight (g/mol); nON = no. of hydrogen bond acceptor; nOHNH = no. of hydrogen bond donors; Nrot = no. of rotatable bonds; TPSA = total polar surface area; MLogP = predicted octanol/water ...

The oxygen cost of eccentric exercise is lower than that of concentric exercise at similar work-loads. In this study, the response to eccentric cycle exercise training (EET) in addition to general ...